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Candida glabrata complicating in vitro pregnancy: successful management of subsequent pregnancy.
MedLine Citation:
PMID:  20840882     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To report the occurrence of Candida glabrata chorioamnionitis complicating an in vitro fertilization (IVF) pregnancy.
DESIGN: Case report.
SETTING: University hospital.
PATIENT(S): A 30-year-old woman, primagravida, with an IVF dichorionic-diamniotic pregnancy who presented at 15 weeks with vaginal bleeding.
INTERVENTION(S): Before embryo transfer in next IVF cycle, vaginal culture from the patient revealed colonization with C. glabrata, which was treated with boric acid.
MAIN OUTCOME MEASURE(S): Subsequent pregnancy after eradication of fungal organisms.
RESULT(S): The patient's first pregnancy was treated with indomethacin and broad-spectrum antibiotics, but her membranes ruptured, and she delivered both twins at 16 weeks; the autopsy and pathology reports were consistent with C. glabrata chorioamnionitis. After boric acid treatment eradicated the organisms, two embryos were transferred in subsequent IVF treatment; the second pregnancy was uncomplicated, with dichorionic-diamniotic twins, delivered by cesarean section at 38 weeks.
CONCLUSION(S): Eradication of vaginal colonization with C. glabrata may prevent infection of the next IVF pregnancy.
Authors:
Obehi A Asemota; Paul Nyirjesy; Rachel Fox; Jack D Sobel
Publication Detail:
Type:  Journal Article     Date:  2010-09-16
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  803.e1-2     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
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