Document Detail

Candida arthritis in adult patients who are not intravenous drug addicts: report of three cases and review of the literature.
MedLine Citation:
PMID:  8484130     Owner:  NLM     Status:  MEDLINE    
Candida species are an uncommon cause of infectious arthritis, although the frequency has increased during recent years. Three cases of septic arthritis caused by Candida species are reported, and the literature is reviewed. The first patient developed a popliteal cyst infected by Candida albicans after multiple intravenous antibiotic treatments. The second patient had acute myelogenous leukemia and experienced knee arthritis after chemotherapy, and the third suffered oligoarthritis after a second heart transplantation. All patients received treatment with a standard dose of intravenous amphotericin B. Responses were achieved only in the first two cases; the third patient died despite therapy. Thirty-six previously reported Candida arthritis cases are reviewed, and epidemiologic, diagnostic, therapeutic, and prognostic features are analyzed. Cases are divided into two categories: direct inoculation of fungus and hematogenously disseminated disease; these two categories are compared in terms of sex, age, pathogen species, treatment, and survival. Arthritis induced through direct inoculation of fungus is seen in older individuals, is more frequently produced by species other than C albicans (Candida parapsilosis especially), and has a better prognosis than arthritis caused by disseminated candidiasis. Arthritis can be resolved even in the persistence of the systemic disease. It is believed that the first case of Baker's cyst infected by C albicans and the first case of Candida arthritis in a heart transplant patient are reported here.
E Cuende; C Barbadillo; R E-Mazzucchelli; C Isasi; A Trujillo; J L Andréu
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  22     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-06-01     Completed Date:  1993-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-41     Citation Subset:  IM    
Servicio de Reumatologia, Clinica Puerta de Hierro, Madrid, Spain.
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MeSH Terms
Amphotericin B / therapeutic use
Arthritis, Infectious / drug therapy,  microbiology*
Candidiasis / complications*,  radiography
Heart Transplantation
Immunocompromised Host
Injections, Intra-Articular
Knee Joint*
Leukemia, Myeloid, Acute / complications,  drug therapy
Middle Aged
Popliteal Cyst / drug therapy,  microbiology*
Postoperative Complications / drug therapy,  microbiology
Reg. No./Substance:
1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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