| Candida albicans cellular internalization: a new pathogenic factor? | |
MedLine Citation:
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PMID: 11118877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preliminary results of a study to show the possibility that Candida albicans can internalize into epithelial cells are reported. The study was performed on buccal, vaginal and HeLa cells. Buccal and vaginal cells, at a concentration of 5 x 10(4) cells/ml and HeLa monolayers were incubated for 2, 3 and 4 h with 10(5) colony forming units of a Candida albicans isolate. After incubation, non-internalised yeasts were eliminated and samples were processed for examination by Scanning Electron Microscopy. Results suggest that receptor-mediated endocytosis could be involved in the pathogenesis of recurrent oral and vaginal infections. This phenomenon could represent an interesting experimental model to testing drug interference in the development of therapeutic strategies against C. albicans infections. |
Authors:
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L Drago; B Mombelli; E De Vecchi; C Bonaccorso; M C Fassina; M R Gismondo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: 16 ISSN: 0924-8579 ISO Abbreviation: Int. J. Antimicrob. Agents Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-20 Completed Date: 2001-02-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 545-7 Citation Subset: IM |
Affiliation:
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Laboratory of Clinical Microbiology, Department of Preclinical Science and L. Sacco Teaching Hospital, University of Milan, L.I.T.A. Vialba, Via G.B. Grassi 74, 20157 Milan, Italy. microbio@mailserver.unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Candida albicans
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physiology*,
ultrastructure Cheek Epithelium / microbiology, physiology, ultrastructure Hela Cells Humans Microscopy, Electron, Scanning Phagocytosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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