Document Detail


Candida albicans cellular internalization: a new pathogenic factor?
MedLine Citation:
PMID:  11118877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preliminary results of a study to show the possibility that Candida albicans can internalize into epithelial cells are reported. The study was performed on buccal, vaginal and HeLa cells. Buccal and vaginal cells, at a concentration of 5 x 10(4) cells/ml and HeLa monolayers were incubated for 2, 3 and 4 h with 10(5) colony forming units of a Candida albicans isolate. After incubation, non-internalised yeasts were eliminated and samples were processed for examination by Scanning Electron Microscopy. Results suggest that receptor-mediated endocytosis could be involved in the pathogenesis of recurrent oral and vaginal infections. This phenomenon could represent an interesting experimental model to testing drug interference in the development of therapeutic strategies against C. albicans infections.
Authors:
L Drago; B Mombelli; E De Vecchi; C Bonaccorso; M C Fassina; M R Gismondo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  16     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  545-7     Citation Subset:  IM    
Affiliation:
Laboratory of Clinical Microbiology, Department of Preclinical Science and L. Sacco Teaching Hospital, University of Milan, L.I.T.A. Vialba, Via G.B. Grassi 74, 20157 Milan, Italy. microbio@mailserver.unimi.it
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MeSH Terms
Descriptor/Qualifier:
Candida albicans / physiology*,  ultrastructure
Cheek
Epithelium / microbiology,  physiology,  ultrastructure
Hela Cells
Humans
Microscopy, Electron, Scanning
Phagocytosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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