Document Detail


Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.
MedLine Citation:
PMID:  21746947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clotrimazole and bifonazole are highly effective antifungal agents against mucosal Candida albicans infections. Here we examined the effects of low levels of clotrimazole and bifonazole on the ability of C. albicans to adhere, invade, and damage vaginal epithelial cells. Although adhesion and invasion were not affected, damage was greatly reduced upon azole treatment. This clearly indicates that low levels of azoles influence specific activities of C. albicans during distinct stages of vaginal epithelium infections.
Authors:
Betty Wächtler; Duncan Wilson; Bernhard Hube
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-11
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  55     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-18     Completed Date:  2012-01-09     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4436-9     Citation Subset:  IM    
Affiliation:
Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute Jena (HKI), Beutenbergstraße 11a, D-07745 Jena, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / pharmacology*
Candida albicans / drug effects*,  physiology*
Cell Line
Clotrimazole / pharmacology*
Enzyme-Linked Immunosorbent Assay
Epithelial Cells / microbiology*
Female
Humans
Imidazoles / pharmacology*
Vagina / cytology*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Imidazoles; 23593-75-1/Clotrimazole; 60628-96-8/bifonazole
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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