Document Detail


Candida albicans Als3, a multifunctional adhesin and invasin.
MedLine Citation:
PMID:  21115738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Candida albicans is part of the normal human flora, and it grows on mucosal surfaces in healthy individuals. In susceptible hosts, this organism can cause both mucosal and hematogenously disseminated disease. For C. albicans to persist in the host and induce disease, it must be able to adhere to biotic and abiotic surfaces, invade host cells, and obtain iron. The C. albicans hypha-specific surface protein Als3 is a member of the agglutinin-like sequence (Als) family of proteins and is important in all of these processes. Functioning as an adhesin, Als3 mediates attachment to epithelial cells, endothelial cells, and extracellular matrix proteins. It also plays an important role in biofilm formation on prosthetic surfaces, both alone and in mixed infection with Streptococcus gordonii. Als3 is one of two known C. albicans invasins. It binds to host cell receptors such as E-cadherin and N-cadherin and thereby induces host cells to endocytose the organism. Als3 also binds to host cell ferritin and enables C. albicans to utilize this protein as a source of iron. Because of its multiple functions and its high expression level in vivo, Als3 is a promising target for vaccines that induce protective cell-mediated and antibody responses. This review will summarize the multiple functions of this interesting and multifunctional protein.
Authors:
Yaoping Liu; Scott G Filler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-11-29
Journal Detail:
Title:  Eukaryotic cell     Volume:  10     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-06-30     Revised Date:  2014-02-12    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biofilms / growth & development*
Candida albicans / immunology,  pathogenicity,  physiology*
Candidiasis / immunology,  prevention & control
Cell Adhesion
Fungal Proteins / metabolism*
Fungal Vaccines
Humans
Iron / metabolism
Protein Binding
Protein Structure, Tertiary
Sequence Homology
Streptococcus gordonii / growth & development
Grant Support
ID/Acronym/Agency:
R01 AI054928/AI/NIAID NIH HHS; R01 AI054928-06/AI/NIAID NIH HHS; R01 DE017088/DE/NIDCR NIH HHS; R01 DE017088-08/DE/NIDCR NIH HHS; R01AI054928/AI/NIAID NIH HHS; R01DE017088/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/ALS3 protein, Candida albicans; 0/Fungal Proteins; 0/Fungal Vaccines; E1UOL152H7/Iron
Comments/Corrections

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