| Candesartan cilexetil in hypertension: effects of six weeks' treatment on haemodynamics, baroreceptor sensitivity and the renin-angiotensin-aldosterone system. | |
| | |
MedLine Citation:
|
PMID: 10697305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of the angiotensin II receptor blocker candesartan cilexetil on systemic and forearm haemodynamics and baroreceptor sensitivity were evaluated in this randomized, placebo-controlled, double-blind, crossover study. After a 4-week placebo run-in period, 22 patients with essential hypertension (diastolic blood pressure 100-114 mmHg) were randomized to receive either candesartan cilexetil 16 mg or placebo once daily for 6 weeks. At the end of each period, 24 h after the last dose, invasive haemodynamic assessments were performed. Simultaneously, the plasma renin activity and plasma concentrations of angiotensin II, aldosterone and catecholamines were measured. Compared to placebo, candesartan cilexetil significantly reduced mean arterial pressure by 8 mmHg (95% CI: 2.6; 12.3), while cardiac output, stroke volume and heart rate were unchanged. Forearm vascular resistance was reduced by 1 mmHg x ml(-1) x L x min (CI: 0.3; 2.3). The baroreceptor sensitivity was not influenced, but a change in the set-point was noted. Plasma renin activity and angiotensin II concentrations were increased, while the aldosterone concentration was significantly reduced. Plasma catecholamine concentrations were unaffected. In conclusion, 6 weeks' treatment with candesartan cilexetil 16 mg o.d. induced systemic and forearm vasodilatation and a reduction in blood pressure without compromising cardiac performance. The plasma concentration of aldosterone was reduced. |
| | |
Authors:
|
K U Fridman; M Wysocki; P R Friberg; O K Andersson |
Related Documents
:
|
16522995 - Resistant or difficult-to-treat hypertension. 10661485 - Saline-resistant metabolic alkalosis, severe hypokalemia and hypertension in a 74-year-... 15229305 - Serum aldosterone and the incidence of hypertension in nonhypertensive persons. 7960015 - Chronic administration of aldosterone depresses baroreceptor reflex function in the dog. 21921085 - Relationship between late-life hypertension, blood pressure, and alzheimer's disease. 3436885 - Effects of hyperoxia on vasoconstriction and va/q matching in the neonatal lung. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Blood pressure Volume: 8 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1999 |
Date Detail:
|
Created Date: 2000-03-24 Completed Date: 2000-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 242-7 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. katarina.fridman@hassle.se.astra.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antihypertensive Agents / therapeutic use Baroreflex / drug effects Benzimidazoles / administration & dosage* Biphenyl Compounds / administration & dosage* Blood Pressure / drug effects Cross-Over Studies Double-Blind Method Forearm / blood supply, physiology Hemodynamics / drug effects Humans Hypertension / drug therapy* Middle Aged Prodrugs / therapeutic use Receptors, Angiotensin / antagonists & inhibitors Renin-Angiotensin System / drug effects Tetrazoles* Time Factors Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Prodrugs; 0/Receptors, Angiotensin; 0/Tetrazoles; 145040-37-5/candesartan cilexetil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Similar central hemodynamics in salt-sensitive and salt-resistant hypertensive patients.
Next Document: Health economics and orthopaedics.