| Cancers and the concept of cell senescence. | |
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MedLine Citation:
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PMID: 19609709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The post-mitotic cell reached by normal cell populations after serial divisions has been regarded as the hallmark of cell senescence. It was proposed that this non-dividing cell is a mechanism of protection against malignant transformation and different approaches have been used to induce the post-mitotic state. There are contradictions and paradoxes between the concepts and the data, which are described herein. There are also contradictions between data from different laboratories that attempted to identify the mechanisms leading to the post-mitotic cell. The contradictions are bypassed with the claim that there are different pathways to cell senescence. The contradictions and the differences between the data should be explained before these phenomena can be understood. |
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Authors:
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Alvaro Macieira-Coelho |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-07-17 |
Journal Detail:
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Title: Biogerontology Volume: 11 ISSN: 1389-5729 ISO Abbreviation: Biogerontology Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930043 Medline TA: Biogerontology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 211-27 Citation Subset: IM |
Affiliation:
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INSERM, 73 Bis Rue Marechal Foch, Versailles, France. macieiracoelho@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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pathology,
physiology Animals Cell Aging / physiology* Cell Differentiation / physiology Cell Division / physiology Cell Proliferation Cell Transformation, Neoplastic / pathology* Female Humans Male Neoplasms / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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