| Cancerostatics. IV. On the synthesis of some noval 1-Azacarbazole derivatives as antineoplastic agents. | |
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MedLine Citation:
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PMID: 7255278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By condensation of 2-chloro-3-nitropyridine with some anilines the corresponding 2-anilino-3-nitropyridines 1a--11 were obtained. Hydrogenation of these compounds and subsequent diazotization of the 2-anilino-3-aminopyridine derivatives 2a--2l gave triazoles 3a--3l which thermally decomposed in PPA or in liquid paraffine afforded the required 6- and 8-substituted 1-azacarbazole derivatives 4a--3, i--l. Some of these compounds showed significant activity against transplanted mouse sarcoma 180. None of them were active against L 1210 and P 388 leukemias. |
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Authors:
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L Kaczmarek; P Nantka-Namirski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Polish journal of pharmacology and pharmacy Volume: 33 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1981 Jan-Feb |
Date Detail:
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Created Date: 1981-09-22 Completed Date: 1981-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
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Languages: eng Pagination: 121-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis*, pharmacology Indoles / chemical synthesis* Mice Neoplasms, Experimental / drug therapy Pyridines / chemical synthesis |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Indoles; 0/Pyridines |
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