Document Detail


Cancer of the uterine cervix: clinical value of squamous cell carcinoma antigen (SCC) measurements.
MedLine Citation:
PMID:  9066575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical value of SCC levels has been evaluated in four groups of women affected by cervical carcinoma. Among the 116 newly diagnosed patients, the SCC pretreatment level was elevated in 57% of cases and was strictly correlated with clinical stage (Ib to IV: p = < 0.01) and histotype (squamous cell carcinoma versus others: p = 0.0005). No significant difference was found in relation to nodal status. For the 28 patients submitted to neoadjuvant chemotherapy clinical response was correlated with the change in serum SCC level: stable or rising serum level indicated that the disease was unchanged or progressive, respectively. In the group of 48 patients affected by recurrent carcinoma, a raised SCC level was found in 71% of cases, with a lead time ranging from 0 to 12 months. No identification of the site of recurrence could be extrapolated from the value of SCC. As to the 108 regularly monitored patients, no significant difference in the risk to develop recurrence was shown for patients with a raised SCC level at the time of primary diagnosis (NED) versus relapsed: p = > 0.05).
Authors:
L Lozza; M Merola; R Fontanelli; B Stefanon; E Seregni; E Bombardieri; G De Palo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  17     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-03-28     Completed Date:  1997-03-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  525-9     Citation Subset:  IM    
Affiliation:
Division of Radiotherapy A, Istituto Nazionale Tumori, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm / blood*
Antineoplastic Agents / therapeutic use
Chemotherapy, Adjuvant
Cisplatin / therapeutic use
Female
Humans
Middle Aged
Neoplasm Recurrence, Local / blood*
Neoplasm Staging
Serpins*
Tumor Markers, Biological / blood*
Uterine Cervical Neoplasms / drug therapy,  immunology*,  pathology,  surgery
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antineoplastic Agents; 0/Serpins; 0/Tumor Markers, Biological; 0/squamous cell carcinoma-related antigen; 15663-27-1/Cisplatin

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