| Cancer and the tumor microenvironment: a review of an essential relationship. | |
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MedLine Citation:
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PMID: 19083000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The role of the microenvironment during the initiation and progression of carcinogenesis is now realized to be of critical importance, both for enhanced understanding of fundamental cancer biology, as well as exploiting this source of relatively new knowledge for improved molecular diagnostics and therapeutics. METHODS: This review focuses on: (1) the approaches of preparing and analyzing secreted proteins, (2) the contribution of tumor microenvironment elements in cancer, and (3) the potential molecular targets for cancer therapy. RESULTS: The microenvironment of a tumor is an integral part of its physiology, structure, and function. It is an essential aspect of the tumor proper, since it supplies a nurturing environment for the malignant process. A fundamental deranged relationship between tumor and stromal cells is essential for tumor cell growth, progression, and development of life threatening metastasis. Improved understanding of this interaction may provide new and valuable clinical targets for cancer management, as well as risk assessment and prevention. Non-malignant cells and secreted proteins from tumor and stromal cells are active participants in cancer progression. CONCLUSIONS: Monitoring the change in the tumor microenvironment via molecular and cellular profiles as tumor progresses would be vital for identifying cell or protein targets for cancer prevention and therapy. |
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Authors:
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Flaubert Mbeunkui; Donald J Johann |
Publication Detail:
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Type: Journal Article; Review Date: 2008-12-14 |
Journal Detail:
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Title: Cancer chemotherapy and pharmacology Volume: 63 ISSN: 1432-0843 ISO Abbreviation: Cancer Chemother. Pharmacol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-01-27 Completed Date: 2009-03-31 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 7806519 Medline TA: Cancer Chemother Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 571-82 Citation Subset: IM |
Affiliation:
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Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA. fmbeunk@ncsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Extracellular Matrix
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pathology Humans Neoplasm Proteins / physiology* Neoplasms / physiopathology* Stromal Cells / pathology |
| Grant Support | |
ID/Acronym/Agency:
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Z99 CA999999/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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