Document Detail

Cancer treatment-induced bone loss: pathophysiology and clinical perspectives.
MedLine Citation:
PMID:  18305064     Owner:  NLM     Status:  MEDLINE    
Hormone-ablative therapies for breast or prostate cancer can cause marked and rapid reductions in circulating estrogen or testosterone levels, resulting in significant effects on bone metabolism and cancer treatment-induced bone loss (CTIBL). Most patients with cancer are over the age of 65 and are already at risk for osteoporosis. Thus, accelerated bone loss from CTIBL is especially concerning in this population. Although there are currently no approved therapies for the treatment or prevention of CTIBL, oral bisphosphonates have been used in settings other than oncology to treat bone loss. New-generation i.v. bisphosphonates have demonstrated promising activity in preventing CTIBL in patients receiving hormonal therapy for breast or prostate cancer. In particular, zoledronic acid not only prevents CTIBL in both breast and prostate cancer patients but also increases bone mineral density above baseline. Such agents have the potential to delay or prevent CTIBL in patients receiving hormonal therapies.
Adam M Brufsky
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The oncologist     Volume:  13     ISSN:  1083-7159     ISO Abbreviation:  Oncologist     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
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MeSH Terms
Antineoplastic Agents, Hormonal / administration & dosage,  adverse effects*
Aromatase Inhibitors / adverse effects
Bone Density Conservation Agents / therapeutic use
Bone Resorption / chemically induced,  physiopathology*,  prevention & control*
Breast Neoplasms / drug therapy*
Diphosphonates / therapeutic use
Imidazoles / therapeutic use
Osteoporosis / prevention & control
Prostatic Neoplasms / drug therapy*
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Aromatase Inhibitors; 0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Imidazoles; 118072-93-8/zoledronic acid

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