| Cancer therapy using bone-seeking isotopes. | |
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MedLine Citation:
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PMID: 8912378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone pain is a common symptom in disseminated malignancy and may be difficult to manage effectively. Radiation is of proven benefit for pain palliation and there is growing interest in the therapeutic potential of bone-seeking radiopharmaceuticals. Clinical data relating to the use of phosphorus-32, strontium-89, samarium-153 EDTMP, rhenium-186 HEDP and tin-117m DTPA are reviewed in the context of the pathophysiology of metastatic bone pain. Possible mechanisms of action of palliative radiotherapy and, in particular, the theoretical role of early response genes are discussed. The application of Monte Carlo simulation to targeted radiotherapy for bone metastases may provide the basis for a clearer understanding of the microdosimetry and radiobiology of bone pain palliation and for reliable prediction of clinical response and toxicity. |
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Authors:
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V J Lewington |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Physics in medicine and biology Volume: 41 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-02-21 Completed Date: 1997-02-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2027-42 Citation Subset: IM |
Affiliation:
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Southampton University Hospitals NHS Trust, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Neoplasms
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physiopathology,
radiotherapy,
secondary* Humans Neoplasms / radiotherapy* Palliative Care Phosphorus Radioisotopes / pharmacokinetics, therapeutic use Radioisotopes / chemistry, pharmacokinetics*, therapeutic use Radiotherapy Dosage Rhenium / pharmacokinetics, therapeutic use Samarium / pharmacokinetics, therapeutic use Strontium / pharmacokinetics, therapeutic use Tin Radioisotopes / pharmacokinetics, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Radioisotopes; 0/Radioisotopes; 0/Tin Radioisotopes; 7440-15-5/Rhenium; 7440-19-9/Samarium; 7440-24-6/Strontium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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