Document Detail


Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor?
MedLine Citation:
PMID:  23348734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The major constituent of green tea, (-)-epigallocatechin-3-O-gallate (EGCG), has been shown to have cancer-preventive and therapeutic activities. Numerous molecular targets for EGCG have been proposed, but the mechanisms of its anticancer activities are not clearly understood. In this issue of the JCI, Kumazoe et al. report that EGCG activates 67-kDa laminin receptor (67LR), elevates cGMP levels, and induces cancer cell apoptosis. Furthermore, a phosphodiesterase 5 inhibitor, vardenafil, synergizes with EGCG to induce cancer cell death. This is a provocative observation with important implications for cancer therapy. It also raises several issues for further investigation, such as the mechanism by which EGCG specifically activates 67LR.
Authors:
Chung S Yang; Hong Wang
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-25
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-05-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology*
Cyclic GMP / metabolism*
Female
Humans
Male
Neoplasms / metabolism*,  pathology*
Receptors, Laminin / metabolism*
Grant Support
ID/Acronym/Agency:
CA120915/CA/NCI NIH HHS; CA122474/CA/NCI NIH HHS; CA133021/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Laminin; H2D2X058MU/Cyclic GMP
Comments/Corrections
Comment On:
J Clin Invest. 2013 Feb 1;123(2):787-99   [PMID:  23348740 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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