Document Detail


Cancer testis antigen expression in gastrointestinal stromal tumors: new markers for early recurrence.
MedLine Citation:
PMID:  18646188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer testis antigens (CTAs) are expressed in a variety of malignant tumors but not in any normal adult tissues except germ cells and occasionally placenta. Because of this tumor-associated pattern of expression, CTAs are regarded as potential vaccine targets. The expression of CTAs in gastrointestinal stromal tumors (GIST) has not been analyzed systematically previously. The present study was performed to analyze the expression of CTA in GIST and to determine if CTA expression correlates with prognosis. Thirty-five GIST patients were retrospectively analyzed for their expression of CTAs by immunohistochemistry using the following monoclonal antibodies (mAb/antigen): MA454/MAGE-A1, M3H67/MAGE-A3, 57B/MAGE-A4, CT7-33/MAGE-C1 and E978/NY-ESO-1. Fourteen tumors (40%) expressed 1 or more of the 5 CTAs tested. Fourteen percent (n = 5/35) were positive for MAGE-A1, MAGE-A3 or MAGE-A4, respectively. Twenty-six percent (n = 9/35) stained positive for MAGE-C1 and 20% (n = 7/35) for NY-ESO-1. A highly significant correlation between CTA expression and tumor recurrence risk was observed (71% vs. 29%; p = 0.027). In our study population, the high-risk GIST expressed CTAs more frequently than low-risk GIST (p = 0.012). High-risk GISTs which stained positive for at least 1 CTA, recurred in 100% (n = 25) of the cases. This is the first study analyzing CTA expression in GIST and its prognostic value for recurrence. The CTA staining could add information to the individual patient prognosis and represent an interesting target for future treatment strategies.
Authors:
Daniel Perez; Thomas Herrmann; Achim A Jungbluth; Pierre Samartzis; Giulio Spagnoli; Nicolas Demartines; Pierre-Alain Clavien; Silvia Marino; Burkhardt Seifert; Dirk Jaeger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  123     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1551-5     Citation Subset:  IM    
Affiliation:
Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal / immunology
Antigens, Neoplasm / immunology*
Child
Disease-Free Survival
Female
Gastrointestinal Stromal Tumors / immunology*,  pathology
Humans
Immunohistochemistry
Male
Middle Aged
Testis / immunology*
Tumor Markers, Biological / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; 0/Tumor Markers, Biological

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