Document Detail


Cancer stem cells and tumor dormancy.
MedLine Citation:
PMID:  23143975     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The cancer stem cell hypothesis postulates that only a subpopulation of cancer cells in a tumor is capable of initiating, sustaining, and reinitiating tumors, while the bulk of the population comprises non-stem cancer cells that lack tumor initiation potential. The interactions of these two phenotypically distinct populations can provoke various nonlinear growth kinetics in the emerging tumor. An environmentally independent, intrinsic dormant state is an inevitable early tumor progression bottleneck within a range of biologically realistic cell kinetic parameters. In certain conditions, cell kinetics can combine to enable escape to tumor progression, yielding morphologically distinct self-metastatic expansion of multiple self-limiting tumor clones.
Authors:
Heiko Enderling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  734     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-71     Citation Subset:  IM    
Affiliation:
Center of Cancer Systems Biology, Steward Research & Specialty Projects Corp., St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge St., Boston, MA, 02135, USA, heiko.enderling@tufts.edu.
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