Document Detail


Cancer stem cells and resistance to chemo and radio therapy.
MedLine Citation:
PMID:  22202026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer stem cells (CSCs, or tumor initiating cells) are responsible for tumor initiation. If cancer treatment kills most of cancer cells in the stage of transit amplifying and differentiation without killing the stem cells, the surviving CSCs will eventually lead to recurrence of tumors. Studies have suggested that CSCs may be the primary mediators of resistance to chemo- and radio-therapy, leading to failure in cancer therapy. Numerous targets are being investigated for their potential involvement in the self-renewal and chemo- and radio-resistance of cancer cells. However, despite the intensive efforts invested into characterizing the role of cancer stem cells, there is a sense of uncertainty regarding the identity and number of these cells as well as the implications in cancer treatment. In this review, we will discuss the identification of CSCs by cell surface markers, the biology of CSCs, and the role of CSCs in resistance to radio- and chemo-therapy. This review will discuss the advances in targeting CSCs to improve the efficacy of chemo- and radio-therapy.
Authors:
Babar Malik; Daotai Nie
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  4     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2012  
Date Detail:
Created Date:  2011-12-28     Completed Date:  2012-05-14     Revised Date:  2012-06-28    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2142-9     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Simmons Cancer Institute, Springfield, IL 62794-9626, USA.
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MeSH Terms
Descriptor/Qualifier:
Drug Resistance, Neoplasm
Humans
Neoplasms / drug therapy*,  pathology,  radiotherapy*
Neoplastic Stem Cells / pathology*
Radiation Tolerance
Grant Support
ID/Acronym/Agency:
R01 CA131445/CA/NCI NIH HHS; R15 CA133776/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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