Document Detail


Cancer stem cells and epithelial ovarian cancer.
MedLine Citation:
PMID:  21318146     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic "stem-cell" properties. Cancer stem cells (CSCs), or tumour-initiating cells, have the ability to self-renew, generate xenografts reminiscent of the primary tumour that they were derived from, and are chemoresistant. The characterisation of the CSC population within a tumour that drives its growth could provide novel target therapeutics against these cells specifically, eradicating the cancer completely. There have been several reports describing the isolation of putative cancer stem cell populations in several cancers; however, no defined set of markers has been identified that conclusively characterises "stem-like" cancer cells. This paper highlights the current experimental approaches that have been used in the field and discusses their limitations, with specific emphasis on the identification and characterisation of the CSC population in epithelial ovarian cancer.
Authors:
Sheetal Dyall; Simon A Gayther; Dimitra Dafou
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Publication Detail:
Type:  Journal Article     Date:  2011-01-24
Journal Detail:
Title:  Journal of oncology     Volume:  2010     ISSN:  1687-8469     ISO Abbreviation:  J Oncol     Publication Date:  2010  
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-07-14     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  101496537     Medline TA:  J Oncol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  105269     Citation Subset:  -    
Affiliation:
Gynaecological Cancer Research Laboratory, EGA UCL Institute for Women's Health, London WC1E 6DD, UK.
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