Document Detail

Cancer stem cells and epithelial ovarian cancer.
MedLine Citation:
PMID:  21318146     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic "stem-cell" properties. Cancer stem cells (CSCs), or tumour-initiating cells, have the ability to self-renew, generate xenografts reminiscent of the primary tumour that they were derived from, and are chemoresistant. The characterisation of the CSC population within a tumour that drives its growth could provide novel target therapeutics against these cells specifically, eradicating the cancer completely. There have been several reports describing the isolation of putative cancer stem cell populations in several cancers; however, no defined set of markers has been identified that conclusively characterises "stem-like" cancer cells. This paper highlights the current experimental approaches that have been used in the field and discusses their limitations, with specific emphasis on the identification and characterisation of the CSC population in epithelial ovarian cancer.
Sheetal Dyall; Simon A Gayther; Dimitra Dafou
Related Documents :
2125036 - A comparative case-control study of colorectal cancer and adenoma.
19109816 - Microsatellite instability and dna ploidy in colorectal cancer: potential implications ...
19077256 - Dietary preference, physical activity, and cancer risk in men: national health insuranc...
17600846 - The use of folic acid antagonists and the risk of colorectal cancer.
8852306 - A morphological study of the fibrous capsule of the human lumbar facet joint.
24834236 - Bayesian correction for mortality trend of oral cavity cancer.
Publication Detail:
Type:  Journal Article     Date:  2011-01-24
Journal Detail:
Title:  Journal of oncology     Volume:  2010     ISSN:  1687-8469     ISO Abbreviation:  J Oncol     Publication Date:  2010  
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-07-14     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  101496537     Medline TA:  J Oncol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  105269     Citation Subset:  -    
Gynaecological Cancer Research Laboratory, EGA UCL Institute for Women's Health, London WC1E 6DD, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Beverage-specific alcohol sale and cardiovascular mortality in Russia.
Next Document:  The Use of HRP in Decolorization of Reactive Dyes and Toxicological Evaluation of Their Products.