Document Detail


Cancer risk related to genetic polymorphisms in carcinogen metabolism and DNA repair.
MedLine Citation:
PMID:  8474997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chemical carcinogenesis involves metabolism in the body of the carcinogen to the ultimate carcinogen and its interaction with DNA. There is considerable interindividual variation in the metabolic ability to activate as well as detoxify the carcinogens and in the ability to repair the carcinogen-DNA adducts. In many cases such differences occur as genetic polymorphisms and form the basis for variation in susceptibility to carcinogens and thereby to cancer risk. The activation mechanism is particularly related to the cytochromes P-450 (CYPs), and four of these are known to activate carcinogens: CYP1A1, CYP1A2, CYP2E1, and CYP3A4. Increased cancer risk has been related to polymorphisms in the CYPs and other activating enzymes. The DNA repair mechanisms show considerable complexity, and deficient repair mechanisms in certain human disorders are clearly related to increased cancer risk. Yet, there is no unambiguous epidemiological evidence available for cancer risk among individuals in general. In vivo methods have to be refined and developed for use in epidemiological studies.
Authors:
H E Poulsen; S Loft; K Wassermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  72 Suppl 1     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-05-19     Completed Date:  1993-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  93-103     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Health Science Faculty, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / metabolism*,  toxicity
DNA Damage
DNA Repair*
Humans
Neoplasms / chemically induced*,  genetics
Polymorphism, Genetic*
Risk
Chemical
Reg. No./Substance:
0/Carcinogens

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