Document Detail

Cancer risk in patients with Graves' disease: a nationwide cohort study.
MedLine Citation:
PMID:  23421548     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported.
METHODS: Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model.
RESULTS: The incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort (p<0.001). Compared with patients aged 20-34 years, older age groups demonstrated a higher risk of developing cancer (35-49 years: hazard ratio (HR)=4.15; 50-64 years: HR=7.39;≥65 years: HR=13.4). After adjusting for sex, age, and comorbidities, the HR for developing breast cancer and thyroid cancer was 1.58- and 10.4-fold higher for patients with GD. Furthermore, the incidence rates (IRR) were the highest in the first three years: 2.06 [confidence interval (CI)=1.87-2.27] and 15.6 [CI=13.9-17.5] in breast cancer and thyroid cancer with GD respectively. Specifically, a 16-fold hazard of developing thyroid cancer was present in the first three years in the GD cohort compared to the non-GD cohort [CI=7.95-32.1].
CONCLUSIONS: GD patients have a higher risk of cancer, particularly thyroid and breast cancer sequent within six and three years respectively. Strategies for preventing thyroid and breast cancer are proposed.
Yen-Kung Chen; Cheng-Li Lin; Yen-Jung Chang; Fiona Tsui-Fen Cheng; Chiao-Ling Peng; Fung-Chang Sung; Ya-Hsin Cheng; Chia-Hung Kao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  23     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-09     Completed Date:  2014-01-27     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  879-84     Citation Subset:  IM    
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MeSH Terms
Breast Neoplasms / epidemiology,  etiology*
Graves Disease / complications*,  epidemiology
Longitudinal Studies
Middle Aged
Neoplasms / epidemiology,  etiology
Proportional Hazards Models
Risk Factors
Taiwan / epidemiology
Thyroid Neoplasms / epidemiology,  etiology*
Comment In:
Thyroid. 2014 Feb;24(2):402-3   [PMID:  23931639 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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