Document Detail


Cancer phenomics: RET and PTEN as illustrative models.
MedLine Citation:
PMID:  17167516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer phenomics, the systematic acquisition and objective documentation of host and/or somatic cancer phenotypic data at many levels, is a young field compared with other molecular-based 'omics'. Two relatively advanced phenomic paradigms are associated with phosphatase and tensin homologue (PTEN) and rearranged during transfection (RET), genes that are associated with cancer predisposition syndromes in addition to developmental disorders. The phenomic characterization of PTEN and RET underscores the importance of incorporating robust phenomics into the host 'omic' profile, and shows that the evolution of phenomics will be crucial to the advancement of personalized medicine.
Authors:
Kevin M Zbuk; Charis Eng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-12-14
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  7     ISSN:  1474-175X     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-03-23     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-45     Citation Subset:  IM    
Affiliation:
Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
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MeSH Terms
Descriptor/Qualifier:
Evolution, Molecular
Gene Expression Profiling
Genomics / methods
Humans
Models, Genetic
Mutation
Neoplasms / genetics*,  metabolism*
PTEN Phosphohydrolase / genetics*
Phenotype*
Proteomics / methods
Proto-Oncogene Proteins c-ret / genetics*
Signal Transduction
Transfection
Chemical
Reg. No./Substance:
EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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