Document Detail


Cancer of the nasal cavity in the pediatric population.
MedLine Citation:
PMID:  18086819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this work was to investigate the clinical manifestations and diagnostic range of malignant entities presenting as a nasal mass in the pediatric population. PATIENTS AND METHODS: A retrospective cohort analysis was conducted at a specialty hospital and a tertiary care university hospital. Patients aged between birth and 18 years and diagnosed with a malignancy that arose within the nasal cavity between the years 1991 and 2006 were included. This institution-specific patient group was compared with a similar cohort of patients extracted from the national Surveillance Epidemiology and End Results database. The main outcome measures were the incidence, presentation, and diagnoses of nasal cancer presenting in this population. RESULTS: Sixteen patients with nasal malignancies presented institutionally in the defined pediatric age group. Patient age at the time of diagnosis ranged from 7 months to 17 years, with a slight male predominance. The main presenting symptoms were unilateral nasal congestion and ophthalmologic complaints. The median time from presentation to diagnosis was 7 weeks; patients who presented with nonspecific complaints, such as nasal obstruction, headache, and fatigue, were given a diagnosis, on average, later than those who presented with focal manifestations. Nationwide, 47 patients were identified from the Surveillance Epidemiology and End Results database. In both subject groups, the most common diagnoses were rhabdomyosarcoma (37.5% institutionally and 23% in the Surveillance Epidemiology and End Results group) and esthesioneuroblastoma (25% institutionally and 28% Surveillance Epidemiology and End Results). In the Surveillance Epidemiology and End Results cohort, the overall mean survival rate was 188 months. CONCLUSIONS: Nasal cancer in the pediatric population often presents with nonspecific signs and symptoms, and a high index of suspicion is necessary for a timely diagnosis. Soft tissue sarcomas are expectedly common. The relative high frequency of esthesioneuroblastoma is particularly noteworthy.
Authors:
Margo McKenna Benoit; Neil Bhattacharyya; William Faquin; Michael Cunningham
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Publication Detail:
Type:  Journal Article     Date:  2007-12-17
Journal Detail:
Title:  Pediatrics     Volume:  121     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e141-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA. margo_benoit@meei.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Distribution
Biopsy, Needle
Child
Child, Preschool
Cohort Studies
Combined Modality Therapy
Esthesioneuroblastoma, Olfactory / epidemiology,  pathology,  therapy
Female
Follow-Up Studies
Humans
Immunohistochemistry
Incidence
Infant
Male
Nasal Cavity / pathology*
Nasal Mucosa / pathology
Neoplasm Staging
Nose Neoplasms / epidemiology*,  pathology*,  therapy
Registries
Retrospective Studies
Rhabdomyosarcoma / epidemiology,  pathology,  therapy
Risk Assessment
SEER Program
Sex Distribution
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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