| Cancer: a matter of life cycle? | |
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MedLine Citation:
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PMID: 17936649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the last decade, the concept of "cancer stem cells" has emerged, recognised by the fact that only a small fraction of tumour cells appears to retain the stem cell properties of self-renewal and unlimited proliferation. At the same time, it is well known that cancer is an age-related disease developing at the limit of proliferating cell senescence. The apparent need to link senescence and the capacity for self-renewal has lead some authors to suggest that cancers develop from amongst senescing stem cells. However, an alternative solution has recently been proffered by Sundaram M, Guernsey DL, Rajaraman MM, Rajaraman R [Neosis: a novel type of cell division in cancer. Cancer Biol Ther 2004;3:207-18], who suggest that stemness may be a transient, cyclic property afforded by de-polyploidisation of senescing cells which have undergone polyploidisation. In this mini-review, we attempt to reconcile both of these views by the idea that cycling polyploidy intermitting senescence and rejuvenation may be features of a life cycle analogous to the life cycles of certain unicellular organisms. Furthermore, we suggest that mitotic catastrophe may represent a mechanism through which the cell can switch from the usual mitotic cell-cycle to this evolutionarily conserved life cycle. Intriguingly, some most recent data suggest that cell senescence may be reversible and that stem cells are tolerant to polyploidy caused by genotoxic stress. |
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Authors:
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Jekaterina Erenpreisa; Mark S Cragg |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-09-02 |
Journal Detail:
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Title: Cell biology international Volume: 31 ISSN: 1065-6995 ISO Abbreviation: Cell Biol. Int. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-10-26 Completed Date: 2008-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 1507-10 Citation Subset: IM |
Affiliation:
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Latvian Biomedical Research and Studies Centre, Riga, Latvia. katrina@biomed.lu.lv |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Aging* Cell Cycle Cell Death Cell Division Cell Transformation, Neoplastic / genetics*, pathology* Humans Life Cycle Stages Mitosis Neoplastic Stem Cells / pathology Polyploidy Stem Cells / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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