Document Detail


Cancer incidence among pharmaceutical workers.
MedLine Citation:
PMID:  7618057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: A cluster of cancers at one plant in a pharmaceutical company in Sweden was the initiator for this work, which describes the cancer incidence among the laboratory and production workers at this company. METHODS: The investigation is a retrospective cohort study. All employees with possible exposure to chemical, pharmacological, or biological agents and employment for at least six months at the company during 1960-1990 were included. Standardized incidence ratios (SIR) were calculated with the local county population as reference. RESULTS: The total cancer incidence was close to the expected. In a subcohort consisting of the highest exposed employees, an SIR of 3.5 [95% confidence interval (95% CI) 1.5-6.8] was found for urothelial tumors, while there were no urothelial tumors among the workers with the lowest exposure. An evaluation of the exposures among the subjects with urothelial tumors revealed no association with specific exposures in the workplaces. There was also a statistically significant increase in the risk for acute leukemia (SIR 4.5, 95% CI 1.2-12 ). With a 10-year induction-latency period in the calculations, the elevated risk was smaller and not significant. Although the numbers were small, there were also statistically significant overrisks for cancer of the peritoneum, the lip, and the pleura. CONCLUSIONS: A significant increase in the risk for urothelial tumors was found among pharmaceutical workers. All but one of those with urothelial tumors were smokers, but confounding from smoking could probably not explain the risk increase.
Authors:
C Edling; L Friis; Z Mikoczy; L Hagmar; P Lindfors
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  21     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-24     Completed Date:  1995-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  116-23     Citation Subset:  IM    
Affiliation:
Department of Occupational and Environmental Medicine, University Hospital, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Cohort Studies
Drug Industry*
Female
Humans
Leukemia / chemically induced,  epidemiology
Male
Mortality
Neoplasms / chemically induced,  epidemiology*
Occupational Exposure / adverse effects*
Retrospective Studies
Risk
Sweden / epidemiology
Urologic Neoplasms / chemically induced,  epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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