Document Detail

Cancer in ataxia-telangiectasia patients: analysis of factors leading to radiation--induced and spontaneous tumors.
MedLine Citation:
PMID:  3541778     Owner:  NLM     Status:  MEDLINE    
Persons with the genetic, autosomal recessive human disorder ataxia-telangiectasia (A-T) have a predisposition to cancer, though the reason for this is not understood. Studies carried out in recent years have provided evidence that cultured skin fibroblasts from A-T patients are hypersensitive to X-radiation and radiomimetic drugs. These cells were also found to release a clastogenic factor and an angiogenesis-like factor into the conditioned medium. Similar factors present in the plasma of A-T patients may be the cause of chromosomael breakage and blood vessel proliferation respectively. It is suggested to that continual chromosomal breakage in lymphocytes, induced by the clastogenic factor, leads to a selection of T or B lymphocytes with neoplastic properties. Future studies should be directed towards skin Langerhans cells to determine their role in the immune deficiency and their interaction with other cellular elements in the skin of A-T patients. Furthermore, T and B lymphocytes from A-T patients with tumors should be cultivated in vitro to study the nature of the activated oncogenes and the possible role of viruses in blood neoplasms in A-T patients.
Y Becker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Anticancer research     Volume:  6     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1986 Sep-Oct
Date Detail:
Created Date:  1987-02-06     Completed Date:  1987-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1021-32     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis
Amyloid beta-Protein Precursor
Ataxia Telangiectasia / complications*,  genetics
Carrier Proteins / analysis
Cathepsin D / analysis
Cell Line
Fibroblasts / enzymology
Leukemia / etiology*
Lymphoma / etiology*
Neoplasms, Radiation-Induced / etiology*
Receptors, Cell Surface
Skin / radiation effects
Skin Neoplasms / etiology*
Warts / etiology
Reg. No./Substance:
0/Amyloid beta-Protein Precursor; 0/Carrier Proteins; 0/Receptors, Cell Surface; 0/protease nexins; EC D

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