| Cancer chemotherapy during pregnancy. Consortium of cancer in pregnancy evidence. | |
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MedLine Citation:
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PMID: 11212430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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QUESTION: I have an 8-weeks' pregnant patient who was diagnosed with stage III Hodgkin's disease last week. The oncologist suggests delaying chemotherapy until the second trimester. What are the effects of chemotherapy on a fetus after the first trimester? Where can I find reliable information on the subject? ANSWER: Available data suggest that exposure to chemotherapy during the first trimester of pregnancy is associated with increased risk of major malformations. Exposure during the second and third trimesters does not result in major malformations, but could have nonteratogenic effects, such as low birth weight. The brain develops throughout pregnancy, and it could be affected later in pregnancy. |
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Authors:
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M Lishner; G Koren |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian family physician Médecin de famille canadien Volume: 47 ISSN: 0008-350X ISO Abbreviation: Can Fam Physician Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-12 Completed Date: 2001-03-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0120300 Medline TA: Can Fam Physician Country: Canada |
Other Details:
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Languages: eng Pagination: 41-2 Citation Subset: IM |
Affiliation:
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Hospital for Sick Children in Toronto. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Adult Antineoplastic Agents / administration & dosage, adverse effects* Brain / abnormalities, embryology Female Hodgkin Disease / drug therapy Humans Pregnancy Pregnancy Complications, Neoplastic / drug therapy* Pregnancy Trimester, First Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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