| Cancer chemoprotective effects of Curcuma xanthorrhiza. | |
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MedLine Citation:
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PMID: 18350518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Curcuma xanthorrhiza Roxb. (Zingiberaceae) is a medicinal plant widely spread in South East Asia. In particular, it is commonly used not only for food and medicinal purposes in Indonesia, but also for the topical treatment of acne and skin inflammations as Thai traditional medicine. It was found that the methanol extract of C. xanthorrhiza inhibited significantly 7,12-dimethylbenz[a]anthracene (DMBA)-induced bacterial mutagenesis of Salmonella typhimurium TA98 and TA100 in the presence of S9, and the mutagenesis induced by H2O2 and tert-butylhydroperoxide in S. typhimurium TA102, respectively. In addition, 12-O-tetradecanolyphorbol-13-acetate(TPA)-induced mouse ear edema was markedly inhibited by pretreatment with C. xanthorrhiza extract. C. xanthorrhiza extract dose-dependently reduced ODC expression in mouse skin with TPA-induced acute inflammation. Furthermore, repeated treatment with 0.1% C. xanthorrhiza extract reduced the average number of tumors per mouse and the percentage of tumor-bearing mice in a multistage mouse skin carcinogenesis induced by DMBA and TPA. These results demonstrate that the methanol extract of C. xanthorrhiza possesses cancer chemopreventive potential. |
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Authors:
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Jae Hee Park; Kwang Kyun Park; Mi Jeong Kim; Jae Kwan Hwang; Sun Kyu Park; Won Yoon Chung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 22 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-05 Completed Date: 2008-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 695-8 Citation Subset: IM |
Affiliation:
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Department of Oral Biology, Yonsei University College of Dentistry, Seoul 120-752, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene Animals Anticarcinogenic Agents / chemistry, pharmacology*, therapeutic use Curcuma / chemistry* Dose-Response Relationship, Drug Ear / pathology Edema / chemically induced, prevention & control Female Humans Methanol / chemistry Mice Mice, Inbred ICR Mutagenesis Phytotherapy Plant Extracts / chemistry, pharmacology*, therapeutic use Salmonella typhimurium / drug effects, genetics Skin Neoplasms / chemically induced, prevention & control* Tetradecanoylphorbol Acetate |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Plant Extracts; 16561-29-8/Tetradecanoylphorbol Acetate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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