Document Detail

Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr.
MedLine Citation:
PMID:  11090965     Owner:  NLM     Status:  MEDLINE    
Seven labdane-type diterpenoids from the stem bark of Thuja standishii (Gord.) Carr. (Cupressaceae) and their analogues showed strong inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Among these compounds, 15,16-bisnor-13-oxolabda-8(17), 11E-dien-19-oic acid was revealed to have the strongest inhibitory effect on the EBV-EA activation, being stronger than that of beta-carotene which has been intensively studied in cancer prevention using animal models. 15,16-bisnor-13-Oxolabda-8(17), 11E-dien-19-oic acid was also found to exhibit the excellent anti-tumor promoting activity in two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene and TPA.
R Tanaka; H Ohtsu; M Iwamoto; T Minami; H Tokuda; H Nishino; S Matsunaga; A Yoshitake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  161     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, 569-1094, Osaka, Japan.
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MeSH Terms
Antigens, Viral / metabolism
Carboxylic Acids / chemistry,  pharmacology*
Diterpenes / chemistry,  pharmacology*
Mice, Inbred ICR
Naphthalenes / chemistry,  pharmacology*
Nasopharyngeal Neoplasms / prevention & control
Neoplasms / prevention & control*
Papilloma / prevention & control
Plant Extracts / chemistry,  pharmacology*
Plant Stems
Skin Neoplasms / chemically induced,  prevention & control
Tetradecanoylphorbol Acetate
beta Carotene / pharmacology
Reg. No./Substance:
0/15,16-bisnor-13-oxolabda-8(17),11-dien-19-oic acid; 0/Antigens, Viral; 0/Carboxylic Acids; 0/Carcinogens; 0/Diterpenes; 0/Epstein-Barr virus early antigen; 0/Naphthalenes; 0/Plant Extracts; 16561-29-8/Tetradecanoylphorbol Acetate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 7235-40-7/beta Carotene

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