| Cancer cell dynamics in presence of telomerase inhibitors: analysis of in vitro data. | |
| | |
MedLine Citation:
|
PMID: 12413877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The inhibition of telomerase activity in actively dividing cells leads to suppression of cell growth after a time delay (inhibitory delay) required to reach a threshold telomeric DNA size. We developed a mathematical model of the dynamics of telomere size distribution and cell growth in the presence of telomere inhibitors that allowed quantification of the inhibitory delay. The model based on the solution of a system of differential equations described quantitatively recent experimental data on dynamics of cultured cells in presence of telomerase inhibitors. The analysis of the data by this model suggested the existence of at least two distinct subpopulations of cells with different proliferative activity. Size distribution of telomeres, fraction of proliferating cells, and tumor doubling times are of critical importance for the dynamics of cancer cells growth in presence of telomerase inhibitors. Rapidly growing cells with large telomeric DNA heterogeneity and small proliferating fractions as well as those with very short homogeneous telomeres would be the most sensitive to telomerase inhibitors. |
| | |
Authors:
|
Igor A Sidorov; Ken S Hirsch; Calvin B Harley; Dimiter S Dimitrov |
Related Documents
:
|
12883667 - Adenoviral p16/cdkn2 gene transfer to malignant glioma: role of p16 in growth, invasion... 15354417 - Effect of all-trans retinoic acid on telomerase activity in ovarian cancer cells. 17350587 - Immortalization and characterization of human dental pulp cells with odontoblastic diff... 16211557 - The first missense alteration in the mcph1 gene causes autosomal recessive microcephaly... 16740217 - Comet assay of cumulus cells and spermatozoa dna status, and the relationship to oocyte... 21332337 - Expression of cd19(+)cd5(+)b cells and iga1-positive cells in tonsillar tissues of iga ... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of theoretical biology Volume: 219 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 2002 Nov |
Date Detail:
|
Created Date: 2002-11-04 Completed Date: 2003-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: England |
Other Details:
|
Languages: eng Pagination: 225-33 Citation Subset: IM |
Affiliation:
|
National Cancer Institute, NIH, Bldg. 469, PO Box B, Frederick, MD 21702, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Death Cell Division Cell Line Enzyme Inhibitors / therapeutic use* Humans Models, Genetic* Neoplasms / drug therapy*, pathology Telomerase / antagonists & inhibitors* Telomere / physiology*, ultrastructure Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modelling natural burst firing in nigral dopamine neurons.
Next Document: A mathematical model for estimating muscle tension in vivo during esophageal bolus transport.