Document Detail

Cancer associated haemolytic uraemic syndrome developing prior to treatment with cytotoxic agents.
MedLine Citation:
PMID:  8381916     Owner:  NLM     Status:  MEDLINE    
The haemolytic uraemic syndrome has been reported in children and adults with neoplasias treated with mitomycin C and occasionally in adults prior to chemotherapeutic treatment, but it has not been reported in a child prior to the use of cytotoxic drugs. This case report concerns the development of the haemolytic uraemic syndrome in a 7-year-old male child with a metastatic hepatocellular carcinoma. The child had persisting haemolysis and renal impairment, and died three weeks after presentation. Though our experience with similar tumours suggested the outlook would be poor, we had hoped to provide palliative chemotherapy. This proved impossible as optimal chemotherapy could not be used because of the renal impairment.
D V Milford; A Goldstein; M Barrett; J R Mann; F Raafat
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  21     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-03-12     Completed Date:  1993-03-12     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  142-5     Citation Subset:  IM    
Department of Paediatric Oncology, Children's Hospital, Birmingham, England.
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MeSH Terms
Anemia, Hemolytic / etiology
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carcinoma, Hepatocellular / complications*,  drug therapy,  secondary
Hemolytic-Uremic Syndrome / etiology*
Liver Neoplasms / complications*,  drug therapy
Lung Neoplasms / secondary

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