Document Detail

Cancer Response Criteria and Bone Metastases: RECIST 1.1, MDA and PERCIST.
MedLine Citation:
PMID:  20842228     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Response criteria represent the standard by which the efficacy of therapeutic agents is determined in cancer trials. The most widely used criteria are based on the anatomic measurement of solid tumors. Because bone metastases are typically located in irregularly shaped bones and are difficult to measure with rulers, they have been previously considered unmeasurable disease. New developments in cancer response criteria have increased awareness of the importance of the response of bone metastases to therapy. The recently updated Response Evaluation Criteria in Solid Tumors (RECIST 1.1) now consider bone metastases with soft tissue masses > 10 mm to be measurable disease. Response criteria specific to bone metastases have been developed at The University of Texas MD Anderson Cancer Center (MDA criteria) and can be used to assess therapeutic response in numerous types of bone metastases. Functional imaging criteria, such as the recently developed Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) allow response to be measured in the absence of anatomic change through assessment of metabolic activity. As monitoring tumor response of bone metastases becomes more important in the management of cancer, so does the demand on radiologists and nuclear medicine physicians for accurate interpretation of the behavior of these lesions. This article reviews anatomic, bone, and metabolic response criteria, providing illustrations for the interpretation of therapy-induced change in bone metastases.
Colleen M Costelloe; Hubert H Chuang; John E Madewell; Naoto T Ueno
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Publication Detail:
Type:  Journal Article     Date:  2010-06-28
Journal Detail:
Title:  Journal of Cancer     Volume:  1     ISSN:  1837-9664     ISO Abbreviation:  J Cancer     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-15     Completed Date:  2011-07-14     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101535920     Medline TA:  J Cancer     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  80-92     Citation Subset:  -    
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