Document Detail


Cancer mortality of workers exposed to styrene in the U.S. Reinforced plastics and composite industry.
MedLine Citation:
PMID:  23344212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidemiologic studies have reported increased risk of lymphohematopoietic cancers, lung cancer, and pancreatic cancer after exposure to styrene, although findings across studies are not consistent.
METHODS: We update a large study of reinforced plastic industry workers with relatively high exposures to styrene, examining cancer risks associated with exposure levels. The study includes 15,826 workers who were exposed between 1948 and 1977 with vital-status follow-up from 1948 to 2008. We examine mortality rates associated with cumulative exposure, duration of exposure, peak exposures, average exposure, and time since first exposure to styrene. Exposure estimates were truncated starting in 1977, the period with the lowest exposures, leaving 27% of the study group with incomplete work histories.
RESULTS: The standardized mortality ratios were 0.84 (95% confidence interval = 0.69-1.02) for all lymphatic and hematopoietic cancers combined, 0.72 (0.50-1.00) for non-Hodgkin lymphoma, and 0.84 (0.60-1.14) for leukemia. There was no trend with either cumulative exposure to styrene or number of peaks. Pancreatic cancer deaths were at expected levels (0.96 [0.73-1.22]). There were more lung cancer deaths than expected (1.34 [1.23-1.46]), although with a marked inverse trend with cumulative exposure.
CONCLUSION: We found no coherent evidence that styrene exposure increases risk from cancers of the lymphatic and hematopoietic tissue, pancreas, or lung.
Authors:
James J Collins; Kenneth M Bodner; James S Bus
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  24     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-23     Revised Date:  2014-01-17    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-203     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cause of Death
Female
Follow-Up Studies
Humans
Leukemia / chemically induced*,  mortality
Lung Neoplasms / chemically induced*,  mortality
Lymphoma / chemically induced*,  mortality
Male
Occupational Exposure / adverse effects*,  statistics & numerical data
Pancreatic Neoplasms / chemically induced*,  mortality
Proportional Hazards Models
Risk
Styrene / adverse effects*
United States
Chemical
Reg. No./Substance:
44LJ2U959V/Styrene
Comments/Corrections
Comment In:
Epidemiology. 2014 Jan;25(1):161-2   [PMID:  24296937 ]
Epidemiology. 2014 Jan;25(1):160-1   [PMID:  24296936 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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