Cancer control and functional outcomes after radical prostatectomy as markers of surgical quality: analysis of heterogeneity between surgeons at a single cancer center.

Cancer control and functional outcomes after radical prostatectomy as markers of surgical quality: analysis of heterogeneity between surgeons at a single cancer center.

MedLine Citation:	PMID: 21095055 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	BACKGROUND: Previous studies have shown that complications and biochemical recurrence rates after radical prostatectomy (RP) vary between different surgeons to a greater extent than might be expected by chance. Data on urinary and erectile outcomes, however, are lacking. OBJECTIVE: In this study, we examined whether between-surgeon variation, known as heterogeneity, exists for urinary and erectile outcomes after RP. DESIGN, SETTING, AND PARTICIPANTS: Our study consisted of 1910 RP patients who were treated by 1 of 11 surgeons between January 1999 and July 2007. INTERVENTION: All patients underwent RP at Memorial Sloan-Kettering Cancer Center. MEASUREMENTS: Patients were evaluated for functional outcome 1 yr after surgery. Multivariable random effects models were used to evaluate the heterogeneity in erectile or urinary outcome between surgeons, after adjustment for case mix (age, prostate-specific antigen, pathologic stage and grade, comorbidities) and year of surgery. RESULTS AND LIMITATIONS: We found significant heterogeneity in functional outcomes after RP (p<0.001 for both urinary and erectile function). Four surgeons had adjusted rates of full continence <75%, whereas three had rates >85%. For erectile function, two surgeons in our series had adjusted rates <20%; another two had rates >45%. We found some evidence suggesting that surgeons' erectile and urinary outcomes were correlated. Contrary to the hypothesis that surgeons "trade off" functional outcomes and cancer control, better rates of functional preservation were associated with lower biochemical recurrence rates. CONCLUSIONS: A patient's likelihood of recovering erectile and urinary function may differ depending on which of two surgeons performs his RP. Functional preservation does not appear to come at the expense of cancer control; rather, both are related to surgical quality.

Authors:	Andrew Vickers; Caroline Savage; Fernando Bianco; John Mulhall; Jaspreet Sandhu; Bertrand Guillonneau; Angel Cronin; Peter Scardino
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Publication Detail:	Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-11-10
Journal Detail:	Title: European urology Volume: 59 ISSN: 1873-7560 ISO Abbreviation: Eur. Urol. Publication Date: 2011 Mar
Date Detail:	Created Date: 2011-03-18 Completed Date: 2011-07-27 Revised Date: 2012-09-24
Medline Journal Info:	Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: Switzerland
Other Details:	Languages: eng Pagination: 317-22 Citation Subset: IM
Copyright Information:	Copyright © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Affiliation:	Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. vickersa@mskcc.org
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MeSH Terms
Descriptor/Qualifier:	Cancer Care Facilities / standards, statistics & numerical data Comorbidity Erectile Dysfunction / epidemiology General Surgery / standards, statistics & numerical data Humans Laparoscopy / standards, statistics & numerical data Male Middle Aged Neoplasm Recurrence, Local / epidemiology Outcome Assessment (Health Care) / standards, statistics & numerical data Postoperative Complications / epidemiology Prostatectomy / methods, standards, statistics & numerical data Prostatic Neoplasms / epidemiology, surgery* Treatment Outcome Urination Disorders / epidemiology
Grant Support
ID/Acronym/Agency:	P50 CA092629-08/CA/NCI NIH HHS; P50-CA92629/CA/NCI NIH HHS
Comments/Corrections
Comment In:	Eur Urol. 2011 Mar;59(3):323-4 [PMID: 21185116 ]

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