Document Detail

Cancer-Associated Fibroblast and M2 Macrophage markers together predict outcome in Colorectal Cancer patients.
MedLine Citation:
PMID:  23298232     Owner:  NLM     Status:  Publisher    
Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts (CAFs) and M2 macrophages, characterized by a high expression of different markers, including α-SMA, FSP1 and FAP, or CD163 and DCSIGN, respectively, are involved in the malignancy of different tumors. In this study, the expression of the above markers in CAF and M2 macrophages was analyzed by RT-PCR and IHC in the normal mucosa and tumor tissue from a cohort of 289 colorectal cancer patients. Expression of CAF markers and of M2 markers is associated with the clinical outcome of colorectal cancer patients. Moreover, the combination of CAF and M2 markers identifies three groups of patients with clear differences in the progression of the disease. This combined variable could be a decisive factor in the survival of advanced-stage patients. Taken together, these analyses demonstrate the prognostic involvement of inter-relationships between DCSIGN, CD163, α-SMA, FSP1 and FAP markers in the survival of colon cancer patients.
Mercedes Herrera; Alberto Herrera; Gemma Domínguez; Javier Silva; Vanesa García; José Miguel García; Irene Gómez; Beatriz Soldevilla; Concepción Muñoz; Mariano Provencio; Yolanda Campos-Martin; Antonio García de Herreros; Ignacio Casal; Félix Bonilla; Cristina Peña
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Japanese Cancer Association.
Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain.
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