| Canaloplasty: Three-year results of circumferential viscodilation and tensioning of Schlemm canal using a microcatheter to treat open-angle glaucoma. | |
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MedLine Citation:
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PMID: 21420593 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To report 3-year results of the safety and efficacy of canaloplasty, a procedure involving circumferential viscodilation and tensioning of the inner wall of Schlemm canal to treat open-angle glaucoma. SETTING: Multicenter surgical sites. DESIGN: Nonrandomized multicenter clinical trial. METHODS: This study comprised adult open-angle glaucoma patients having canaloplasty or combined cataract-canaloplasty surgery. Qualifying preoperative intraocular pressures (IOPs) were at least 16 mm Hg with historical IOPs of at least 21 mm Hg. A flexible microcatheter was used to viscodilate the full circumference of the canal and to place a trabecular tensioning suture. Primary outcome measures included IOP, glaucoma medication use, and adverse events. RESULTS: Three years postoperatively, all study eyes (n = 157) had a mean IOP of 15.2 mm Hg ± 3.5 (SD) and mean glaucoma medication use of 0.8 ± 0.9 compared with a baseline IOP of 23.8 ± 5.0 mm Hg on 1.8 ± 0.9 medications. Eyes with combined cataract-canaloplasty surgery had a mean IOP of 13.6 ± 3.6 mm Hg on 0.3 ± 0.5 medications compared with a baseline IOP of 23.5 ± 5.2 mm Hg on 1.5 ± 1.0 medications. Intraocular pressure and medication use results in all eyes were significantly decreased from baseline at every time point (P<.001). Late postoperative complications included cataract (12.7%), transient IOP elevation (6.4%), and partial suture extrusion through the trabecular meshwork (0.6%). CONCLUSION: Canaloplasty led to a significant and sustained IOP reduction in adult patients with open-angle glaucoma and had an excellent short- and long-term postoperative safety profile. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes. |
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Authors:
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Richard A Lewis; Kurt von Wolff; Manfred Tetz; Norbert Koerber; John R Kearney; Bradford J Shingleton; Thomas W Samuelson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cataract and refractive surgery Volume: 37 ISSN: 1873-4502 ISO Abbreviation: J Cataract Refract Surg Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8604171 Medline TA: J Cataract Refract Surg Country: United States |
Other Details:
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Languages: eng Pagination: 682-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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From Grutzmacher & Lewis (Lewis), Sacramento, California; Cataract Care Center (Kearney), Johnstown, New York; Ophthalmic Consultants of Boston (Shingleton), Boston, Massachusetts; Minnesota Eye Consultants (Samuelson), Minneapolis, Minnesota, USA; Augen-Tagesklinik Gross Pankow (von Wolff), Gross Pankow; Eye Center Spreebogen (Tetz), and Berlin Eye Research Institute (BERI), Berlin; and Augencentrum Porz, (Koerber), Koln, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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