Document Detail

Canalicular obstruction: a histopathologic case series.
MedLine Citation:
PMID:  23217503     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To investigate the histopathologic causes of canalicular obstruction in a case series of patients treated by canalicular trephination for symptomatic epiphora.
DESIGN: A university and private practice retrospective chart review.
PARTICIPANTS: The study involved 12 consecutive patients who underwent unilateral canalicular trephination with tissue retrieval for the treatment of canalicular obstruction.
METHODS: Canalicular obstruction was confirmed at the time of preoperative and intraoperative probing and irrigation. Treatment consisted of canalicular trephination combined with silicone intubation and a concomitant dacryocystorhinostomy in 6 cases. Tissue was recovered from the trephine lumen and submitted for pathologic analysis. Predisposing factors that could have caused canalicular obstruction and the clinical course following treatment were reported.
RESULTS: The most common histopathologic finding was nonspecific inflammation with associated fibrosis. Cases demonstrating sebaceous gland adenoma, skeletal muscle, adipose tissue, and bone were identified.
CONCLUSIONS: Use of the lacrimal trephine to open canalicular obstructions provided tissue samples that revealed nonspecific inflammation and fibrosis as a common underlying histopathology. The presence of skeletal muscle and adipose tissue suggests a decrease in canalicular diameter or such dense scarring that the normal canalicular architecture could not be followed. Other causes of canalicular obstruction such as lacrimal sac tumors should be considered in the differential diagnosis.
Kelly R Everman; Craig N Czyz; Kevin Kalwerisky; Robert H Hill; Jill A Foster; Kenneth V Cahill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie     Volume:  47     ISSN:  0008-4182     ISO Abbreviation:  Can. J. Ophthalmol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045312     Medline TA:  Can J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  500-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Canadian Ophthalmological Society. All rights reserved.
Department of Ophthalmology, The Ohio State University, Columbus, Ohio; Department of Ophthalmology, Oral and Maxillofacial Surgery, Grant Medical Center, Columbus, Ohio.
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