| Canalicular cholestasis due to amiodarone toxicity. A definite diagnosis obtained by electron microscopy. | |
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MedLine Citation:
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PMID: 8775470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of jaundice due to canalicular cholestasis during amiodarone therapy is reported. A definite diagnosis was attained by ultrastructural evidence of a phospholipidosis pattern, a characteristic amiodarone-induced injury. Jaundice occurred within the third month of therapy. Serum bilirubin levels continued to increase in the two weeks following drug withdrawal. A slow decrease was observed in the following three months. Only four cases of jaundice associated with amiodarone therapy have been reported until now. |
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Authors:
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G Macarri; G Feliciangeli; V Berdini; A M Jezequel; A Benedetti |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Italian journal of gastroenterology Volume: 27 ISSN: 0392-0623 ISO Abbreviation: Ital J Gastroenterol Publication Date: 1995 Oct-Nov |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000544 Medline TA: Ital J Gastroenterol Country: ITALY |
Other Details:
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Languages: eng Pagination: 436-8 Citation Subset: IM |
Affiliation:
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Clinica di Gastroenterologia e Cattedra di Citopatologia, Università di Ancona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / adverse effects* Anti-Arrhythmia Agents / adverse effects* Bile Canaliculi / pathology* Cholestasis, Intrahepatic / chemically induced*, pathology* Diagnosis, Differential Humans Male Microscopy, Electron* Vasodilator Agents / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Vasodilator Agents; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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