| Canakinumab for the treatment of cryopyrin-associated periodic syndromes. | |
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MedLine Citation:
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PMID: 20069137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Familial cold-induced autoinflammatory syndrome, Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease make up cryopyrin-associated periodic syndromes (CAPS). These are autoinflammatory inherited disorders caused by autosomal dominant gain-of-function mutations in the NLRP3 gene, located on chromosome 1q44. Cryopyrin/NALP3/NLRP3 is an essential component of intracellular inflammasomes that activate caspase-1, which in turn converts interleukin-1beta (IL-1beta) to its active form. IL-1beta is a potent cytokine that activates diverse elements of the immune and inflammatory systems leading to the pathogenic changes characteristic of CAPS. There is therefore much interest in the development of IL-1beta blocking agents as novel biologic treatments for these conditions. Canakinumab (ACZ-885; Ilaris, Novartis Pharma) is a fully humanized monoclonal antibody (mAb) specific for IL-1beta and is indicated for a wide range of inflammatory disorders including CAPS. This review will assess the utility of canakinumab as a treatment for CAPS. |
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Authors:
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Garry M Walsh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs of today (Barcelona, Spain : 1998) Volume: 45 ISSN: 1699-3993 ISO Abbreviation: Drugs Today Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-01-13 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160518 Medline TA: Drugs Today (Barc) Country: Spain |
Other Details:
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Languages: eng Pagination: 731-5 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved. |
Affiliation:
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Division of Applied Medicine, Institute of Medical Science, University of Aberdeen, Foresterhill, Aberdeen, UK. g.m.walsh@abdn.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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adverse effects,
therapeutic use* Carrier Proteins / genetics Clinical Trials as Topic Cryopyrin-associated Periodic Syndromes / drug therapy*, genetics Humans Interleukin-1beta / antagonists & inhibitors*, physiology Mutation |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Carrier Proteins; 0/Interleukin-1beta; 0/NLRP3 protein, human; 0/canakinumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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