| Canadian Glaucoma Study: 3. Impact of risk factors and intraocular pressure reduction on the rates of visual field change. | |
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MedLine Citation:
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PMID: 20696979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine rates of visual field change associated with risk factors for progression in the Canadian Glaucoma Study (abnormal anticardiolipin antibody level, age, female sex, and mean follow-up intraocular pressure [IOP]), and to evaluate the effect of IOP reduction on subsequent rates of visual field change in progressing patients. METHODS: Two hundred sixteen patients (median age, 65.2 years) were followed up at 4-month intervals with perimetry and were monitored for progression. Patients reaching an end point based on total deviation analysis underwent 20% or greater reduction in IOP. Rates of mean deviation (MD) change were calculated. RESULTS: Patients with 0, 1, and 2 end points had a median of 18, 23, and 25 examinations, respectively. The median MD rate in progressing patients prior to the first end point was significantly worse compared with those with no progression (-0.35 and 0.05 dB/y, respectively). An abnormal anticardiolipin antibody level was associated with a significantly worse MD rate compared with a normal anticardiolipin antibody level (-0.57 and -0.03 dB/y, respectively). Increasing age was associated with a worse MD rate, but female sex and mean follow-up IOP were not. After the first end point, the median IOP decreased from 18.0 to 14.8 mm Hg (20% in individual patients), resulting in a significant MD rate change from -0.36 to -0.11 dB/y. CONCLUSIONS: Patients with abnormal anticardiolipin antibody levels and increasing age had faster visual field change. Modest IOP reduction in progressing patients significantly ameliorated the rate of visual field decline. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00262626. |
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Authors:
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Balwantray C Chauhan; Frederick S Mikelberg; Paul H Artes; A Gordon Balazsi; Raymond P LeBlanc; Mark R Lesk; Marcelo T Nicolela; Graham E Trope; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-08-09 |
Journal Detail:
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Title: Archives of ophthalmology Volume: 128 ISSN: 1538-3601 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-10-27 Revised Date: 2010-12-27 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 1249-55 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, Dalhousie University, Victoria, Halifax, Nova Scotia B3H 2Y9, Canada. bal@dal.ca |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00262626 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Anticardiolipin / blood Disease Progression Female Follow-Up Studies Glaucoma, Open-Angle / immunology, physiopathology* Humans Intraocular Pressure / physiology* Male Middle Aged Prospective Studies Risk Factors Tonometry, Ocular Vision Disorders / physiopathology* Visual Acuity / physiology Visual Field Tests Visual Fields / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin |
| Investigator | |
Investigator/Affiliation:
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Paul H Arrtes / ; Balwantray C Chauhan / ; Raymond P LeBlanc / ; Marcelo T Nicolela / ; Paul E Rafuse / ; David M Andrews / ; Mohammad Humayun / ; James MacNeill / ; Andrew C Orr / ; John H Quigley / ; George A Sapp / ; Christine A MacDonald / ; Helen M Sauveur / ; Sara L Lavender / ; A Gordon Balazsi / ; Oscar P Kasner / ; Nabil E Saheb / ; Alan J Coffey / ; W Edward Connolly / ; Marino J Discepola / ; Conrad C Kavalec / ; Susan K Lindley / ; Marc Mullie / ; Pearl Alexander / ; Bonnie May / ; Gordon R Douglas / ; Stephen M Drance / ; Frederick S Mikelberg / ; Jeffrey A Blicker / ; Robin S Cottle / ; Vincent Wong / ; Zarina Pardhan / ; Mark R Lesk / ; Pearl Alexander / ; Bonnie May / ; Yvonne M Buys / ; John G Flanagan / ; Graham E Trope / ; Catherine M Birt / ; Michael W Easterbrook / ; William G Macrae / ; Samuel N Markowitz / ; Maureen Wolpert / ; Emad Eskander / ; Christine A Macgillivray / ; Balwantray C Chauhan / ; Erin Hicks / ; Kathryn Patterson / ; Andrew Vassallo / ; Pantelis Andreou / ; Balwantray C Chauhan / ; Frederick S Mikelberg / ; A Gordon Balazsi / ; Raymond P LeBlanc / ; Mark R Lesk / ; Graham E Trope / ; Frederick S Mikelberg / ; Raymond P LeBlanc / ; Graham E Trope / |
| Comments/Corrections | |
Erratum In:
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Arch Ophthalmol. 2010 Dec;128(12):1633 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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