Document Detail

Can zinc be an adjuvant therapy for juvenile onset recurrent respiratory papillomatosis?
MedLine Citation:
PMID:  17560665     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To report a severe case of juvenile onset recurrent respiratory papillomatosis (JORRP) controlled by zinc replacement therapy. To review the contemporary adjuvant therapies used in JORRP.
METHODS: The trial of zinc was described in terms of its effect on the inter-surgical interval, site score and clinical symptoms. Long-term follow-up with dose adjustment was detailed. Articles reporting trials of adjuvant therapies over the past 20 years were reviewed in terms of regimen used, mode of assessment, side effects and final outcome.
RESULTS: Zinc was effective in decreasing the severity of the disease, the rate of relapse and the need for surgery. There was an obvious relation between the dose used and the degree of improvement. Prolonged treatment seems to be needed to sustain the positive effect. No side effects were noticed over a 45-month follow-up period. The literature does support the role of zinc in modulating the immune system. Eight adjuvant therapies were reviewed as published in 40 reports. Interferon was the most used substance. It is definitely effective but often associated with relapse upon discontinuation. The effect of cidofovir was favorable yet not dramatic as initially expected. Other less commonly used therapies showed humble effects. The HspE7 vaccine seems to be promising awaiting further trials.
CONCLUSIONS: Zinc replacement therapy may benefit JORRP patients with zinc deficiency and should be investigated in more cases. Several adjuvant therapies are available for use in JORRP. They are generally beneficial though mostly not curative.
Mohamed Bitar; Rami Baz; Nabil Fuleihan; Musa Muallem
Related Documents :
22569645 - Evaluation of the prognosis of fulminant viral hepatitis in late pregnancy by the meld ...
22528165 - Star vas - short term atorvastatin regime for vasculopathic subjects: a randomized plac...
22374385 - Late complications after pancreaticoduodenectomy with pancreaticogastrostomy.
22901955 - Task shifting of antiretroviral treatment from doctors to primary-care nurses in south ...
3375875 - Complications of carotid endarterectomy: the influence of case load.
14740285 - Effect of oral camostat mesilate on hematuria and/or proteinuria in children.
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-06-08
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  71     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-10-09     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1163-73     Citation Subset:  IM    
Section of Pediatric Otolaryngology, Department of Otolaryngology-Head & Neck Surgery, American University of Beirut and Medical Center, Beirut, Lebanon.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antiviral Agents / therapeutic use*
Chemotherapy, Adjuvant
Child, Preschool
Cytosine / analogs & derivatives*,  therapeutic use
Drug Therapy, Combination
Laryngeal Neoplasms / drug therapy*,  surgery
Organophosphonates / therapeutic use*
Papilloma / drug therapy*,  surgery
Zinc / therapeutic use*
Reg. No./Substance:
0/Antiviral Agents; 0/Organophosphonates; 71-30-7/Cytosine; 7440-66-6/Zinc; JIL713Q00N/cidofovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relievin...
Next Document:  Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture.