Document Detail


Can you hear me now? Understanding vertebrate middle ear development.
MedLine Citation:
PMID:  21196256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The middle ear is a composite organ formed from all three germ layers and the neural crest. It provides the link between the outside world and the inner ear, where sound is transduced and routed to the brain for processing. Extensive classical and modern studies have described the complex morphology and origin of the middle ear. Non-mammalian vertebrates have a single ossicle, the columella. Mammals have three functionally equivalent ossicles, designated the malleus, incus and stapes. In this review, I focus on the role of genes known to function in the middle ear. Genetic studies are beginning to unravel the induction and patterning of the multiple middle ear elements including the tympanum, skeletal elements, the air-filled cavity, and the insertion point into the inner ear oval window. Future studies that elucidate the integrated spatio-temporal signaling mechanisms required to pattern the middle ear organ system are needed. The longer-term translational benefits of understanding normal and abnormal ear development will have a direct impact on human health outcomes.
Authors:
Susan Caroline Chapman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  16     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-21     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1675-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amphibians / anatomy & histology
Animals
Birds / anatomy & histology
Chondrogenesis / physiology
Ear, Middle / anatomy & histology,  embryology,  growth & development*
Epithelial-Mesenchymal Transition
Eustachian Tube / anatomy & histology
Humans
Mammals / anatomy & histology
Neural Crest / embryology
Organogenesis
Osteogenesis / physiology
Reptiles / anatomy & histology
Signal Transduction / physiology
Tympanic Membrane / anatomy & histology
Grant Support
ID/Acronym/Agency:
DC009236/DC/NIDCD NIH HHS; R01 DC009236/DC/NIDCD NIH HHS; R01 DC009236-02S1/DC/NIDCD NIH HHS; R01 DC009236-04/DC/NIDCD NIH HHS
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