Document Detail

Can we prevent hypospadias?
MedLine Citation:
PMID:  18947788     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Hypospadias is the second most common genital anomaly in children. The etiology of hypospadias remains unknown in the overwhelming majority of patients. Herein, I review the etiology of hypospadias and propose that hypospadias can be explained by a two-hit hypothesis: genetic susceptibility plus environmental exposure to endocrine disruptors. The strategy to prevent hypospadias should be focused on (1) identifying genetic susceptibility prior to pregnancy and (2) identifying and eliminating exposure to potential toxic endocrine disruptors that effect urethral development.
Laurence S Baskin
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Publication Detail:
Type:  Journal Article     Date:  2007-10-24
Journal Detail:
Title:  Journal of pediatric urology     Volume:  3     ISSN:  1873-4898     ISO Abbreviation:  J Pediatr Urol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-10-24     Completed Date:  2009-12-14     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  101233150     Medline TA:  J Pediatr Urol     Country:  England    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  -    
UCSF Children's Hospital, Department of Urology and Pediatrics, 400 Parnassus Avenue, A640, San Francisco, CA 94143, USA.
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Comment In:
J Pediatr Urol. 2012 Apr;8(2):127-8   [PMID:  22182358 ]

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