| Can we prevent hypospadias? | |
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MedLine Citation:
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PMID: 18947788 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Hypospadias is the second most common genital anomaly in children. The etiology of hypospadias remains unknown in the overwhelming majority of patients. Herein, I review the etiology of hypospadias and propose that hypospadias can be explained by a two-hit hypothesis: genetic susceptibility plus environmental exposure to endocrine disruptors. The strategy to prevent hypospadias should be focused on (1) identifying genetic susceptibility prior to pregnancy and (2) identifying and eliminating exposure to potential toxic endocrine disruptors that effect urethral development. |
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Authors:
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Laurence S Baskin |
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Publication Detail:
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Type: Journal Article Date: 2007-10-24 |
Journal Detail:
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Title: Journal of pediatric urology Volume: 3 ISSN: 1873-4898 ISO Abbreviation: J Pediatr Urol Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-10-24 Completed Date: 2009-12-14 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101233150 Medline TA: J Pediatr Urol Country: England |
Other Details:
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Languages: eng Pagination: 420-5 Citation Subset: - |
Affiliation:
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UCSF Children's Hospital, Department of Urology and Pediatrics, 400 Parnassus Avenue, A640, San Francisco, CA 94143, USA. lbaskin@urology.ucsf.edu |
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment In:
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J Pediatr Urol. 2012 Apr;8(2):127-8
[PMID:
22182358
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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