Document Detail

Can we modify the intrauterine environment to halt the intergenerational cycle of obesity?
MedLine Citation:
PMID:  22690193     Owner:  NLM     Status:  MEDLINE    
Child obesity is a global epidemic whose development is rooted in complex and multi-factorial interactions. Once established, obesity is difficult to reverse and epidemiological, animal model, and experimental studies have provided strong evidence implicating the intrauterine environment in downstream obesity. This review focuses on the interplay between maternal obesity, gestational weight gain and lifestyle behaviours, which may act independently or in combination, to perpetuate the intergenerational cycle of obesity. The gestational period, is a crucial time of growth, development and physiological change in mother and child. This provides a window of opportunity for intervention via maternal nutrition and/or physical activity that may induce beneficial physiological alternations in the fetus that are mediated through favourable adaptations to in utero environmental stimuli. Evidence in the emerging field of epigenetics suggests that chronic, sub-clinical perturbations during pregnancy may affect fetal phenotype and long-term human data from ongoing randomized controlled trials will further aid in establishing the science behind ones predisposition to positive energy balance.
Kristi B Adamo; Zachary M Ferraro; Kendra E Brett
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Publication Detail:
Type:  Congresses; Research Support, Non-U.S. Gov't     Date:  2012-04-16
Journal Detail:
Title:  International journal of environmental research and public health     Volume:  9     ISSN:  1660-4601     ISO Abbreviation:  Int J Environ Res Public Health     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-10-16     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101238455     Medline TA:  Int J Environ Res Public Health     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1263-307     Citation Subset:  IM    
Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.
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MeSH Terms
Embryonic Development
Fetal Development
Obesity / epidemiology*
Prenatal Exposure Delayed Effects
Grant Support
//Canadian Institutes of Health Research

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