Document Detail

Can we justify spermatid microinjection for severe male factor infertility?
MedLine Citation:
PMID:  9741706     Owner:  NLM     Status:  MEDLINE    
During 1995 and 1996 the first spermatid pregnancies were announced with both round spermatid (ROSI) and elongated spermatid (ELSI) injections. These publications were flanked by live births from ROSI in a number of animal species, with resulting offspring appearing normal, healthy and fertile. However, the live births in humans heralded a scientific and ethical debate on the clinical use of this technology; and in a number of countries nationwide moratoria prohibiting spermatid microinjection were enjoined. Concerns surrounded the biological condition of spermatids and clinical implications of utilizing an immature spermatozoon for conception. Nevertheless, case reports and a few scientific studies on human spermatid conception have been published in recent years, and further polemic on testicular histopathology and prognosis has ensued. This paper reviews the current arguments on the clinical use of ROSI and ELSI, and evaluates the biology of the main contributory components of a spermatozoon to the subsequent embryo, namely the genetic material, the microtubular organizing complex and the putative oocyte activating factor. We also consider the relevant testicular histopathology and likely outcome in the context of the current birth rate from ROSI and ICSI. We conclude by considering the way forward for infertile men who require this technology to become genetic fathers, and whether the time is now appropriate to consider clinical trials.
I Aslam; S Fishel; S Green; A Campbell; L Garratt; H McDermott; K Dowell; S Thornton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  4     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-11-20     Completed Date:  1998-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  IM    
CARE Centres for Assisted Reproduction, The Park Hospital, Arnold, Nottingham, UK.
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MeSH Terms
Clinical Trials as Topic
Fertilization in Vitro / methods*
Infertility, Male / therapy*
Spermatids* / ultrastructure
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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