| Can warfarin be continued during dental extraction? Results of a randomized controlled trial. | |
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MedLine Citation:
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PMID: 12054719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A randomized controlled trial was set up to investigate whether patients who were taking warfarin and had an International Normalised Ratio (INR) within the normal therapeutic range require cessation of their anticoagulation drugs before dental extractions. Of 109 patients who completed the trial, 52 were allocated to the control group (warfarin stopped 2 days before extraction) and 57 patients were allocated to the intervention group (warfarin continued). The incidence of bleeding complications in the intervention group was higher (15/57, 26%) than in the control group (7/52, 14%) but this difference was not significant. Two patients in the study required hospital review for bleeding and all other episodes of bleeding were controlled by patients at home. Continuing warfarin when the INR is < 4.1 may lead to an increase in minor post-extraction bleeding after dental extractions but we found no evidence of an increase in clinically important bleeding. As there are risks associated with stopping warfarin, the practice of routinely discontinuing it before dental extractions should be reconsidered. |
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Authors:
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I L Evans; M S Sayers; A J Gibbons; G Price; H Snooks; A W Sugar |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The British journal of oral & maxillofacial surgery Volume: 40 ISSN: 0266-4356 ISO Abbreviation: Br J Oral Maxillofac Surg Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-10 Completed Date: 2002-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405235 Medline TA: Br J Oral Maxillofac Surg Country: Scotland |
Other Details:
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Languages: eng Pagination: 248-52 Citation Subset: D; IM |
Copyright Information:
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Copyright 2002 The British Association of Oral and Maxillofacial Surgeons. |
Affiliation:
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Maxillofacial Unit, Morriston Hospital, Swansea, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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therapeutic use Adult Aged Aged, 80 and over Analgesics, Non-Narcotic / therapeutic use Anesthetics, Local / administration & dosage Anticoagulants / administration & dosage, therapeutic use* Chi-Square Distribution Confidence Intervals Female Follow-Up Studies Hemostasis, Surgical Humans International Normalized Ratio Lidocaine / administration & dosage Male Middle Aged Oral Hemorrhage / etiology Postoperative Hemorrhage / etiology Risk Factors Statistics as Topic Tooth Extraction* Warfarin / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 0/Anesthetics, Local; 0/Anticoagulants; 103-90-2/Acetaminophen; 137-58-6/Lidocaine; 81-81-2/Warfarin |
| Comments/Corrections | |
Comment In:
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Br J Oral Maxillofac Surg. 2003 Apr;41(2):132
[PMID:
12694713
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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