Document Detail

Can urinary excretion rate of malondialdehyde, uric acid and protein predict the severity and impending death in perinatal asphyxia?
MedLine Citation:
PMID:  18471999     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Perinatal asphyxia (PA) associated with multi-organ damage is a leading cause of neonatal mortality and morbidity. We evaluated if urinary malondialdehyde:creatinine (UMDA:Cr), uric acid:creatinine (UUA:Cr) and protein:creatinine (UP:Cr) vary with the severity of PA and if these parameters can predict the impending death in PA. METHODS: Study included 20 asphyxiated and 20 healthy newborn males. Hypoxic-ischemic encephalopathy (HIE) staging, APGAR (activity, pulse, grimace, appearance and respiration) score and urinary protein, uric acid, creatinine and MDA were evaluated. RESULTS: UMDA:Cr, UUA:Cr and UP:Cr were significantly higher and correlated with APGAR and HIE in PA. By regression analysis also, urinary parameters were found to have significant association with HIE stage and APGAR in PA. Receiver operating characteristics (ROC) curve of UP:Cr, UUA:Cr and UMDA:Cr showed area under curve of 0.896 (p=0.003), 0.859 (p=0.008) and 0.849 (p=0.010) with cut-off value of 9.04 mg, 2.34 mg and 3.49 microg/mg of creatinine respectively that can optimally predict the impending death in PA. SDS-PAGE of unconcentrated urine detected both high (73 kDa and 68 kDa) and low molecular weight proteins (52 kDa, 47 kDa, 25 kDa and 20 kDa) in PA but not in controls. CONCLUSION: Urinary excretion rate of uric acid, MDA and proteins is higher and has potential to act as biochemical markers for severity evaluation and death prediction in PA.
C Banupriya; Ratnakar; P Doureradjou; N Mondal; Bhat Vishnu; B C Koner
Related Documents :
3811079 - Ammonium urate urinary stones.
12781909 - Effects of sufentanil on the release and metabolism of dopamine and ascorbic acid and g...
8129379 - Application of a novel 1,1'-dimethylferricinium dye for the determination of uric acid ...
6742409 - Measurement of uric acid, ascorbic acid, and related metabolites in biological fluids.
20636849 - The association of serum uric acid levels with outcomes following percutaneous coronary...
6997229 - The effect of acetohydroxamic acid on the induction of bacterial ureases.
23650159 - Transition metal-α-amino acid complexes with antibiotic activity against mycobacterium ...
8138809 - Arachidonic fatty acid in red blood cell membranes, lymphocytes, and cultured skin fibr...
3607069 - Assignment of the aromatic 1h-nmr resonances of myotoxin a isolated from the venom of c...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-23
Journal Detail:
Title:  Clinical biochemistry     Volume:  41     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-73     Citation Subset:  IM    
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apgar Score
Asphyxia Neonatorum / mortality,  urine*
Biological Markers / urine
Creatinine / urine
Electrophoresis, Polyacrylamide Gel
Infant, Newborn
Malondialdehyde / urine*
Oxidative Stress
Predictive Value of Tests
Proteinuria / urine*
Severity of Illness Index
Uric Acid / urine*
Reg. No./Substance:
0/Biological Markers; 542-78-9/Malondialdehyde; 60-27-5/Creatinine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Elevated circulatory MMP-2 and MMP-9 levels and activities in patients with rheumatoid arthritis and...
Next Document:  Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-a...