Document Detail

Can transventricular intracardiac impedance measurement discriminate haemodynamically unstable ventricular arrhythmias in human?
MedLine Citation:
PMID:  17272334     Owner:  NLM     Status:  MEDLINE    
AIMS: To measure changes in transventricular impedance during arrhythmias. METHODS AND RESULTS: Patients were studied during electrophysiological studies. A quadrapolar catheter was positioned at the right ventricular apex (RVA) and a decapolar catheter within the coronary sinus (CS). Transventricular impedance was measured by injecting a subthreshold biphasic rectangular pulse of 600 micro A between poles 1 of the CS catheter and pole 1 of the RVA catheter and the voltage measured between CS pole 10 and RVA catheter pole 4. Stroke impedance (SZ), surface ECG, intracardiac electrogram (IEGM), and invasive femoral artery blood pressure (FAP) were recorded. Twenty-eight patients were analysed, 5 with inducible, haemodynamically unstable ventricular tachycardia (VT) (HUSVT), 5 with stable VT (HSVT). During HUSVT, the SZ value reduced to 22% (range 0.15-0.32 P < 0.001) in comparison with sinus rhythm. For HSVT, the SZ value reduced to 58% (range 0.33-0.88) P < 0.01, significantly different from HUSVT (P < 0.01). There was a good correlation between reduction of SZ and arterial pulse pressure (PP) during arrhythmias (r = 0.95). CONCLUSION: Changes in SZ strongly correlated with PP amplitude. Transventricular impedance fell significantly during unstable arrhythmias and may be useful as a sensor capable of haemodynamic discrimination.
Gerry Kaye; Deborah Edgar; Telal Mudawi; Michael Lippert; Gerald Czygan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  9     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Department of Cardiology, Castle Hill Hospital, East Yorkshire, UK.
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MeSH Terms
Cardiac Pacing, Artificial
Cardiography, Impedance / methods*
Linear Models
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Tachycardia, Ventricular / diagnosis*,  physiopathology*

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