Document Detail

Can thyroid peroxidase be used as a complementary tumor marker besides thyroglobulin? Preliminary experience with determination of TPO in differentiated thyroid carcinomas.
MedLine Citation:
PMID:  9329585     Owner:  NLM     Status:  MEDLINE    
Serum TPO concentrations were studied compared with the hTG levels in 47 patients suffering from different thyroid carcinomas (before and several times after the first, second or third radioiodine therapy respectively. An immunoluminometric coated tube assay was applied recognizing this enzyme (Brahms Diagnostica GmbH). Elevated TPO levels could be seen in 18/47 pts. All of them suffered from large postoperative remnants or metastases. An increase of TPO concentration was seen frequently at days 2 and 3 following the first or second radioidine application. Although the hTG response seems to be more sensitive, TPO may be helpful to reduce the number of false positive hTG findings.
W G Franke; C Schimming; G Wunderlich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  17     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-10-29     Completed Date:  1997-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2999-3002     Citation Subset:  IM    
Klinik und Poliklinik für Nuklearmedizin, Technische Universität Dresden, Germany.
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MeSH Terms
Iodide Peroxidase / blood*
Middle Aged
Thyroglobulin / blood*
Thyroid Neoplasms / blood*
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Tumor Markers, Biological; 9010-34-8/Thyroglobulin; EC Peroxidase

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