| Can tetracycline-induced fatty liver in pregnancy be attributed to choline deficiency? | |
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MedLine Citation:
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PMID: 6183565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant women, especially those in their third trimester, are particularly susceptible to tetracycline-induced fatty liver. Experimental evidence obtained in rats suggest that the precipitous fall in maternal liver choline concentration nearing the end of pregnancy could lead to a severe reduction in the lipotropic activity of the liver. It is hypothesised that the liver in this state will be at much greater risk of developing fatty degeneration, especially if it is exposed to hepatotoxic agents such as tetracycline. |
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Authors:
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M C Gwee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 9 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Choline / metabolism Choline Deficiency / complications* Fatty Liver / chemically induced* Female Humans Lipotropic Agents / metabolism Liver / drug effects Pregnancy Pregnancy Complications / chemically induced* Rats Tetracycline / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Lipotropic Agents; 60-54-8/Tetracycline; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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