| Can a super oral rehydration solution stimulate intestinal repair in acute viral enteritis? | |
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MedLine Citation:
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PMID: 9019010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to screen several treatments for their effects on mucosal repair in an established model of piglet rotavirus enteritis. Six ingredients selected to facilitate repair were added to the oral rehydration solution (ORS) and subsequently to the diet: L-glutamine (GLN); rice solids; a soluble fiber (carboxymethylcellulose); nucleotides; polyamines; and fructooligo-saccharides. Rotavirus infection consistently induced a watery diarrhoea lasting 5 to 10 days and produced a jejunal mucosal lesion which was maximal at 3 days, post-inoculation (manifested by a reduction of villus surface area to 30% to 50% of normal). By 7 to 10 day post-inoculation, the villus surface area returned to 50% to 80% of normal. None of the supplemental ingredients added to the ORS had a significant effect in either shortening the clinical illness or in stimulating recovery of the affected mucosa. It is concluded that several types of "Super ORS" are ineffective in enhancing repair in viral enteritis in neonatal colostrum-deprived piglets. These results do not rule out beneficial effects of the additives tested in subjects with more extensive intestinal damage, in those who receive breast milk, or in those with bacterial enteritis. |
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Authors:
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J M Rhoads; G G Gomez; W Chen; R Goforth; R A Argenzio; M J Neylan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of diarrhoeal diseases research Volume: 14 ISSN: 0253-8768 ISO Abbreviation: J Diarrhoeal Dis Res Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-03-14 Completed Date: 1997-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8402695 Medline TA: J Diarrhoeal Dis Res Country: BANGLADESH |
Other Details:
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Languages: eng Pagination: 175-81 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diarrhea / pathology, therapy, virology Disease Models, Animal Enteritis / pathology, therapy*, virology Fluid Therapy Intestinal Mucosa / drug effects*, pathology Rehydration Solutions / therapeutic use* Rotavirus Infections / pathology, therapy* Swine |
| Chemical | |
Reg. No./Substance:
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0/Rehydration Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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