| Can sugammadex save a patient in a simulated 'cannot intubate, cannot ventilate' situation? | |
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MedLine Citation:
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PMID: 21198485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have shown that the use of high dose rocuronium followed by sugammadex provides a faster time to recovery from neuromuscular blockade following rapid sequence induction than suxamethonium. In a manikin-based 'cannot intubate, cannot ventilate' simulation, we studied the total time taken for anaesthetic teams to prepare and administer sugammadex from the time of their initial decision to use the drug. The mean (SD) total time to administration of sugammadex was 6.7 (1.5) min, following which a further 2.2 min (giving a total 8.9 min) should be allowed to achieve a train-of-four ratio of 0.9. Four (22%) teams gave the correct dose, 10 (56%) teams gave a dose that was lower than recommended, four (22%) teams gave a dose that was higher than recommended, six (33%) teams administered sugammadex in a single dose, and 12 (67%) teams gave multiple doses. Our simulation highlights that sugammadex might not have saved this patient in a 'cannot intubate, cannot ventilate' situation, and that difficulties and delays were encountered when identifying, preparing and administering the correct drug dose. |
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Authors:
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M M A Bisschops; C Holleman; J M Huitink |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anaesthesia Volume: 65 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-01-24 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 936-41 Citation Subset: AIM; IM |
Copyright Information:
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© 2010 The Authors. Journal compilation © 2010 The Association of Anaesthetists of Great Britain and Ireland. |
Affiliation:
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Department of Anesthesiology, VU University Medical Centre, Amsterdam, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstanols
/
antagonists & inhibitors*,
pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Humans Intubation, Intratracheal / contraindications Manikins Neuromuscular Blockade Neuromuscular Junction / drug effects* Neuromuscular Nondepolarizing Agents / antagonists & inhibitors*, pharmacology Respiration, Artificial / contraindications gamma-Cyclodextrins / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 0/Sugammadex; 0/gamma-Cyclodextrins; 143558-00-3/rocuronium |
| Comments/Corrections | |
Comment In:
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Anaesthesia. 2011 Feb;66(2):141-2
[PMID:
21254997
]
Anaesthesia. 2011 Mar;66(3):224-5; author reply 225 [PMID: 21320095 ] Anaesthesia. 2011 Mar;66(3):224 [PMID: 21320094 ] Anaesthesia. 2011 Feb;66(2):139-40 [PMID: 21254994 ] Anaesthesia. 2011 Mar;66(3):223-4 [PMID: 21320093 ] Anaesthesia. 2011 Feb;66(2):140-1; author reply 141 [PMID: 21254995 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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